The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The fundamental building blocks of hierarchically structured bone tissue are mineralized collagen fibrils with calcium phosphate nanocrystals that are biologically “engineered” through biomineralization. In this study, we demonstrate an original invention of dicalcium phosphate anhydrate (DCPA)/poly(lactic acid) (PLA) composite nanofibers, which mimics the mineralized collagen fibrils via biomimetic...
Biodegradable polymer scaffolds are being extensively investigated for uses in tissue engineering because of their versatility in fabrication methods and range of achievable chemical and mechanical properties. In this study, poly(lactic‐co‐glycolic acid) (PLGA) was used to make various types of microspheres that were processed into porous scaffolds that possessed a wide range of properties. A heat...
Techniques to pattern cells on biocompatible hydrogels allow for the creation of highly controlled cell microenvironments within materials that mimic the physicochemical properties of native tissues. Such technology has the potential to further enhance our knowledge of cell biology and to play a role in the development of novel tissue engineering devices. Light is an ideal stimulus to catalyze pattern...
The aim of this study was to evaluate the modulation of matrix metalloproteinase‐2 (MMP‐2) and −9 (MMP‐9) expression in newly formed bone tissue at the interface between implants derived from castor oil (Ricinus communis) polymer and the tibia medullary canal. Forty‐four rabbits were assigned to either Group 1 (n = 12; control) or Group 2 (n = 30), which had the tibial medullary canals reamed bilaterally...
Poly(ε‐caprolactone) (PCL) scaffolds functionalized by grafting nerve growth factor (NGF) and Asp‐Arg‐Gly‐Asp (GRGD)(PCL‐NGF/GRGD) for neural tissue engineering. The influences of PCL‐NGF/GRGD scaffolds on the growth and differentiation of PC12 cells were investigated. The successfully grafting NGF and GRGD into PCL‐CS scaffold were verified by FTIR spectra. The densities of GRGD and NGF in the scaffolds...
Layered adipose‐derived stem cell (ADSC) sheet transplantation is attracting attention as a new stem cell therapeutic strategy for damaged hearts. To prolong the function of tissue‐engineered constructs after transplantation, a rapid and sufficient vascularization of engrafted tissue is essential. The in vitro formation of network structures derived from endothelial cells (ECs) in grafts before transplantation...
How do we quantify cellular alignment? Cellular alignment is an important technique used to study and promote tissue regeneration in vitro and in vivo. Indeed, regenerative outcomes are often strongly correlated with the efficacy of alignment, making quantitative, automated assessment an important goal for the field of tissue engineering. There currently exist various classes of algorithms, which...
Transplantation of cells within poly(ethylene glycol) (PEG) hydrogel scaffolds as effective immunoisolation barriers is becoming increasingly important strategy for tissue engineering and regenerative medicine. In these applications, crosslink density of these membranes has significant effect on the control of diffusion of many biomolecules such as nutrients, cellular wastes, and hormones. When these...
Collagen has been utilized as a scaffold for tissue engineering applications due to its many advantageous properties. However, collagen in its purified state is mechanically weak and prone to rapid degradation. To mitigate these effects, collagen can be crosslinked. Although enhanced mechanical properties and stability can be achieved by crosslinking, collagen can be rendered less biocompatible either...
Poly(β‐amino ester) (PBAE) biodegradable hydrogel systems have garnered much attention in recent years due to their appealing properties for biomedical applications. These hydrogel systems exhibit properties similar to natural soft tissue, degrade in aqueous environments, and have easily tunable properties that have been well studied and understood. In most cases, tissue engineering scaffolds must...
The advantages of endothelialization of a stent surface in comparison with the bare metal and drug‐eluting stents used today include reduced late‐stent restenosis and in‐stent thrombosis. In this article, we study the effect of surface topology and functionalization of tantalum (Ta) with cyclic‐(arginine‐glycine‐aspartic acid‐d‐phenylalanine‐lysine) (cRGDfK) on the attachment, spreading, and growth...
This study examined the effect of hyaluronan (HA) molecular weight on immune response. HA with molecular weights ranging from the unitary disaccharide unit (400 Da) up to 1.7 × 106 Da and with very low endotoxin contamination level (less than 0.03 EU/mg) was used. Primary human monocyte/macrophage cultures were assayed for IL‐1β production under a variety of inflammatory conditions with or without...
Locally applied simvastatin is known to promote bone regeneration; however, the lack of suitable delivery systems has restricted its clinical use. In this study we demonstrate for the first time the use of premixed acidic calcium phosphate cement (CPC) as a delivery system for water‐solubilized simvastatin. Freeze‐dried simvastatin β‐hydroxy acid (SVA) was added to the premixed cement paste in four...
A combined experimental and computational approach was employed to investigate the feasibility and effectiveness of characterizing carbonated apatite (CAp) by infrared (IR) spectroscopy. First, an experimental comparative study was conducted to identify characteristic IR vibrational bands of carbonate substitution in the apatite lattice. The IR spectra of pure hydroxyapatite (HA), carbonate adsorbed...
Scaffolds for bone tissue engineering applications should have suitable degradability in favor of new bone ingrowth after implantation into bone defects. In this study, degradation behavior of polyurethane composites composed of triblock copolymer poly(caprolactone)–poluronic–poly(caprolactone) (PCL–Pluronic–PCL, PCFC) and nanohydroxyapatite (n‐HA) was investigated. The water contact angle and water...
This study investigated the adhesive behaviors of normal and abnormal hematopoietic cells on nanotopographical materials. Previously, electrospun nanofiber scaffolds (NFSs) were used to capture and expand hematopoietic stem cells in vitro; here, we demonstrate that NFS could also serve as a useful bioadhesive platform for capturing functionally adherent leukemia cells. Collagen‐blended poly(d,l‐lactide‐...
The insertion of cochlear implants into the inner ear often causes inflammation and fibrosis inside the scala tympani and thus growth of fibrous tissue on the implant surface. This deposition leads to the loss of function in both electrical and laser‐based implants. The design of this study was to realize fibroblast growth inhibition by dexamethasone (Dex) released from the base material of the implant...
Magnesium and its alloys are candidate materials for biodegradable implants; however, excessively rapid corrosion behavior restricts their practical uses in biological systems. For such applications, surface modification is essential, and the use of anticorrosion coatings is considered as a promising avenue. In this study, we coated Mg with hydroxyapatite (HA) in an aqueous solution containing calcium...
One of the major hurdles to cure cancer lies in the low potency of currently available drugs, which could eventually be solved by using more potent therapeutic macromolecules, such as proteins or genes. However, although these macromolecules possess greater potency inside the cancer cells, the barely permeable cell membrane remains a formidable barrier to exert their efficacy. A widely used strategy...
The effect of chloride‐substitution on bioactivity and osteoconductivity of hydroxyapatite (OHAp) was newly investigated. Chloride‐substituted hydroxyapatites (ClAp) with low and high chloride concentrations were synthesized by reacting Ca(OH)2 and H3PO4 with NH4Cl of low and high concentrations, with subsequent sintering. As a control, pure OHAp was prepared under the same conditions but without...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.